@article{144281,
  keywords = {Escherichia coli, Escherichia coli Proteins, Protein Folding, Gram-Negative Bacteria, Protein Transport, Bacterial Outer Membrane Proteins},
  author = {Dante Ricci and Thomas Silhavy},
  title = {Outer Membrane Protein Insertion by the β-barrel Assembly Machine},
  abstract = {<p>Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally assembled into the growing OM by the ubiquitous β-barrel assembly machine (Bam). While the identities and structures of all essential and accessory Bam components have been determined, the basic mechanism of Bam-assisted OM protein integration remains elusive. Here we review mechanistic analyses of OM β-barrel protein folding and Bam dynamics and summarize recent insights that inform a general model for OM protein recognition and assembly by the Bam complex.</p>
},
  year = {2019},
  journal = {EcoSal Plus},
  volume = {8},
  month = {03/2019},
  issn = {2324-6200},
  doi = {10.1128/ecosalplus.ESP-0035-2018},
  language = {eng},
}