@article{89961,
  keywords = {Cell Count, Bacterial Proteins, Escherichia coli, Genes, Bacterial, Transcription Factors, Gene Expression Regulation, Bacterial, Protein Binding, Escherichia coli Proteins, DNA-Binding Proteins, Sigma Factor, Glucose, Molecular Chaperones, Adenosine Triphosphatases, Bacterial Outer Membrane Proteins, Serine Endopeptidases, Endopeptidase Clp, Water-Electrolyte Balance, ATPases Associated with Diverse Cellular Activities},
  author = {Pratt and Silhavy},
  title = {The response regulator SprE controls the stability of RpoS},
  abstract = {<p>In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter.</p>
},
  year = {1996},
  journal = {Proc Natl Acad Sci U S A},
  volume = {93},
  pages = {2488-92},
  month = {03/1996},
  issn = {0027-8424},
  doi = {10.1073/pnas.93.6.2488},
  language = {eng},
}