@article{90076,
  keywords = {Bacterial Proteins, Mutation, Escherichia coli, Protein Sorting Signals, Suppression, Genetic},
  author = {Bieker and Phillips and Silhavy},
  title = {The sec and prl genes of Escherichia coli},
  abstract = {<p>Two general approaches have been used to define genetically the genes that encode components of the cellular protein export machinery. One of these strategies identifies mutations that confer a conditional-lethal, pleiotropic export defect (sec, secretion). The other identifies dominant suppressors of signal sequence mutations (prl, protein localization). Subsequent characterization reveals that in at least three cases, prlA/secY, prlD/secA, and prlG/secE, both types of mutations are found within the same structural gene. This convergence is satisfying and provides compelling evidence for direct involvement of these gene products in the export process.</p>
},
  year = {1990},
  journal = {J Bioenerg Biomembr},
  volume = {22},
  pages = {291-310},
  month = {06/1990},
  issn = {0145-479X},
  doi = {10.1007/BF00763169},
  language = {eng},
}