@article{90141,
  keywords = {Bacterial Proteins, Gene Expression Regulation, Mutation, Escherichia coli, Genes, Bacterial, Transcription Factors, Bacterial Outer Membrane Proteins, Porins},
  author = {Slauch and Garrett and Jackson and Silhavy},
  title = {EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12},
  abstract = {<p>The regulatory proteins OmpR and EnvZ are both required to activate expression of the genes for the major outer membrane porin proteins, OmpF and OmpC, of Escherichia coli K-12. Here we show that OmpR, under certain conditions, could activate porin expression in the complete absence of EnvZ. In addition, the pleiotropic phenotypes conferred by a particular envZ mutation (envZ473) required the presence of functional OmpR protein. These results lead us to conclude that EnvZ and OmpR act in sequential fashion to activate porin gene expression; i.e., EnvZ modifies or in some way directs OmpR, which in turn acts at the appropriate porin gene promoter.</p>
},
  year = {1988},
  journal = {J Bacteriol},
  volume = {170},
  pages = {439-41},
  month = {01/1988},
  issn = {0021-9193},
  doi = {10.1128/jb.170.1.439-441.1988},
  language = {eng},
}